High Dimensional Convolutional Neural Network for EEG Connectivity-Based Diagnosis of ADHD.

Background: Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children and adults and its early detection is effective in the successful treatment of children. Electroencephalography (EEG) has been widely used for classifying ADHD and normal children. In recent years, deep learning leads to more accurate classification. Objective: This study aims to adapt convolutional neural networks (CNNs) for classifying ADHD and normal children based on the connectivity measure of their EEG signals. Material and Methods: In this experimental study, the dataset consisted of 61 ADHD and 60 normal children from which 13021 epochs were extracted as input for model training and evaluation. Synchronization likelihood (SL) and wavelet coherence (WC) were considered connectivity measures. The neighborhood between EEG channels was arranged in a two-dimensional matrix for better representation. Four-dimensional (4D) and six-dimensional (6D) connectivity tensors were composed as model inputs. Two architectures were developed, one 4D and 6D CNN for SL and WC-based diagnosis of ADHD, respectively. Results: A 5-fold cross-validation was utilized to assess developed models. The average accuracy of 98.56% for 4D CNN and 98.85% for 6D CNN in epoch-based classification were obtained. In the case of subject-based classification, the accuracy was 99.17% for both models. Conclusion: Based on the evaluation metrics of the proposed models, ADHD children can be diagnosed and ADHD and normal children can be successfully distinguished.

Prevalence of epileptiform discharges in children with sensori-neural hearing loss and behavioral problems compared to their normal hearing peers.

OBJECTIVE: Overactivity and behavioral problems are common problems in children with prelingually profound sensorineural hearing loss (SNHL). Data on epileptiform electroencephalography (EEG) discharges in deaf children with psychological disorders are so limited. The primary focus of this study was to determine the prevalence of epileptiform discharges (EDs) in children with SNHL and overactivity or behavioral problems. MATERIALS & METHODS: A total of 262 patients with prelingually profound SNHL who were referred to our cochlear implantation center between 2008 and 2010 were enrolled in this study. Children with SNHL who had diagnosis of overactivity and/or behavioral problems by a pediatric psychiatrist, underwent electroencephalography (EEG). EEG analysis was carried out by a board-certified pediatric neurologist. The control group consisted of 45 cases with overactivity or behavioral problems and normal hearing. RESULTS: One hundred thirty-eight children with mean age of 3.5±1.23 year were enrolled in the case group, of whom 88 cases (63.7%) were boy. The control group consisted of 45 cases with mean age of 3.2±1.53 years, of whom 30 (66.6%) cases were male. EDs were detected in 28 (20.02%) children of the case group (with SNHL) in comparison with 4 (8.88%) in the control group (without SNHL), which was statistically significantly different. CONCLUSION: In this study, we obtained higher frequency of EDs in deaf children with overactivity and/or behavioral problem compared to the children without SNHL. Further studies are required to evaluate the possible association of SNHL with EDs in overactive children.

Sexual function in women after surgery for pelvic organ prolapse.

Our objective was to evaluate the effect of surgical repair of pelvic organ prolapse on female sexual function. Sixty seven women with pelvic organ prolapse were recruited in the study. Degree of pelvic organ prolapse was assessed using pelvic organ prolapse quantitation (POPQ) staging system. Female sexual function index (FSFI) questionnaire was used to assess sexual function of the cases preoperatively and 12-16 weeks after the operation. Mean age of the cases was 36.03 +/- 5.38 years. The total mean FSFI score increased from 15.9 +/- 10.7 to 21.9 +/- 11.1 (P < 0.05). Domain scores of desire, arousal, lubrication, orgasm, and satisfaction were increased significantly (P < 0.05). The mean score for the pain-free intercourse decreased significantly. Results demonstrated that sexual function was improved postoperatively. Using various instruments to assess female sexual function and differences in demographic and cultural characteristics of study groups might be the reasons of discrepancy between the reports.